Antimicrobial Activity and In Silico Molecular Docking Studies of Pentacyclic Spiro[oxindole-2,3′-pyrrolidines] Tethered with Succinimide Scaffolds

Three-component cascade reactions of (E)-3-arylidene-1-methyl-pyrrolidine-2,5-diones, L-valine and various isatin derivatives are described. A series 17 spiropyrrolidine with wide structural complexity diversity have been thus obtained in moderate to excellent yields under mild reaction conditions. The structure stereochemistry these N-heterocyclic cycloadducts has established by spectroscopic techniques unambiguously confirmed a single-crystal X-ray diffraction analysis performed on one derivative. UV-visible spectra recorded for all new compounds. Furthermore, the synthesized compounds screened their vitro antibacterial antifungal activities. Several exhibited good activities, comparable those known standard drugs Amphotericin B Tetracycline. Structural activity relationships (SARs) molecular docking most promising into binding sites glucosamine 6-phosphate synthase (GlcN6P) methionyl-trna-synthetase (1PFV) were also established. pharmacokinetic studies indicate that heterocycles exhibit acceptable predictive ADMET (absorption, distribution, metabolism, excretion, toxicity) properties drug ability.